Zofran and pregnancy- Zofran is a prescription medication that is used to prevent nausea and vomiting. This is the brand name for Ondansetron. It is most often prescribed for cancer patients as a way to prevent nausea and vomiting due to surgery, radiation, and chemotherapy. Sometimes it is prescribed to overcome morning sickness in pregnant women. Zofran can prevent nausea and vomiting by blocking the function of serotonin. Zofran is a serotonin 5-HT3 receptor antagonist.
According to Dr. Nagashree Seetharamu, an oncologist at North Shore Long Island Jewish Cancer Institute at Lake Success in New York, when chemotherapy is administered, this procedure can release serotonin from various structures, including the belly, intestine, and brain. Someone can reflex vomiting when serotonin is released. Zofran can prevent this by interfering the process.
I. Zofran and Pregnancy
Zofran can be prescribed to overcome morning sickness in pregnant women. It can be prescribed as an orally disintegrating tablet (ODT), liquid, and a tablet. The safety of Zofran for fetus a is still under study although Zofran is often effective in preventing nausea or vomiting in pregnant women.
A study in January 2012 looked at more than 4,500 women who experienced nausea and vomiting during pregnancy. The researcher found that taking ondansetron during the first trimester of pregnancy and Zofran second trimester pregnancy was associated with the double risk of Zofran pregnancy birth defects, such as a cleft lip or palate.
However, a study in February 2013, in mothers taking Zofran, it is found no significant risk to the fetus. The FDA stated a potential safety issue for mothers taking Zofran. However, that does not mean the FDA recommends that prescriptions do not prescribe Zofran or the patients should stop taking the medication. However, it is not known whether Zofran enters into breast milk. Pregnant women with questions about Zofran and pregnancy should talk to their doctor.
II. Zofran Pregnancy Dosage
Zofran is available as an oral tablet, rapidly disintegrating tablet (ODT), injection, and a liquid. For cancer patients, the first dose is usually taken one hour before the operation begins, one to two hours before radiation begins, and 30 minutes before chemotherapy begins. Occasionally, patients take an additional dose of one to three times a day during radiation or chemotherapy and two days after end the treatment.
Adults usually consume 10 mL of liquid twice a day or one 8-mg tablet or rapidly disintegrating tablet. The dose of patients age 12 and older is as same as the dose of adults. The patients should take 5 mL of liquid three times per day or a 4-mg tablet or rapidly disintegrating tablets for patient ages 4 to 11.
The patients can continue their normal diet while taking Zofran and this medication can be taken with or without food. However, the patients should not consume alcohol during taking Zofran and pregnancy.
III. FDA Warns Zofran Use in Pregnancy
The FDA has issued a recent warning against Zofran or Ondansetron as their use during pregnancy. Zofran is actually used to prevent nausea and vomiting associated with cancer chemotherapy and surgery that has been approved by the FDA. It is a 5-HT3 receptor antagonist.
Is it safe for a pregnant woman to take ondansetron? Zofran is not allowed to treat nausea and vomiting during pregnancy. The Zofran pregnancy FDA has warned against the use of this medication during pregnancy because recent studies regarding the association between Zofran use and pregnancy was associated with oral cleft lip and palate and congenital cardiac malformations.
There is also a potential risk of pregnant women that is associated with the use of Zofran and pregnancy. That is the electrolyte imbalance. Therefore Zofran has to not be taken by pregnant moms, according to Zofran pregnancy lawsuit.
Pyridoxine hydrochloride and Doxylamine succinate knew as Diclegis are an FDA-approved recipe for morning sickness. These anti-nausea drugs provide the safer alternative for pregnant women who experience nausea and vomiting.
That is the review of Zofran and pregnancy. Read one of the other articles about pregnancy pillow to help you get a comfortable sleep overnight. Also, know the assured pregnancy test if you are expecting a pregnancy and you are wondering if you are pregnant or not.